New Publication from Pharmacy Faculty in Diagnostic Microbiology and Infectious Disease

Congratulations to School of Pharmacy faculty members Dr. Brigg Turner and Dr. Fawzy Elbarbry for their new publication "Prospective evaluation of vancomycin pharmacokinetics in a heterogeneous critically ill population" in Diagnostic Microbiology and Infectious Disease. This study was a collaboration with several infectious disease specialists from Legacy Health System.

From the abstract:

Rich pharmacokinetic data on vancomycin in critically ill patients are lacking. The purpose of this study was to evaluate the pharmacokinetics of vancomycin in this population using rich pharmacokinetic sampling.

Nineteen critically ill patients received individualized vancomycin doses by intermittent infusion to achieve target trough concentrations (15–20 mg/L). Blood samples were collected following the third or later dose of vancomycin. Serial blood samples were collected at 30 min following initiation of the vancomycin infusion; at the end of the infusion; serially at 60, 120, 300, and 480 min after the infusion finished; and immediately prior to the next dose. Vancomycin concentration–time profiles at steady state were fit to a noncompartmental model to determine the pharmacokinetic parameters.